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目的:探讨抑癌基因p21与癌基因cyclinD1在膀胱移行细胞中的表达及意义。方法:采用免疫组织化学S-P染色方法检测66例膀胱移行细胞癌组织中P21,cyclinD1蛋白的表达情况。结果:P21、cyclinD1蛋白在膀胱移行癌Ⅰ,Ⅱ,Ⅲ级中的阳性率分别为31.8%,62.5%;71.8%,80.8%;46.7%,83.3%。在Tis-T1期,T2～4期中的阳性表达分别为41.6%,83.3%,73.3%,30.0%。结论:P21与cyclinD1蛋白在膀胱移行的细胞癌中发挥重要作用,且呈负相关。
Objective: To investigate the expression and significance of tumor suppressor gene p21 and oncogene cyclinD1 in bladder transitional cell. Methods: Immunohistochemical S-P staining was used to detect the expression of P21 and cyclinD1 protein in 66 cases of bladder transitional cell carcinoma. Results: The positive rates of P21 and cyclinD1 in grade Ⅰ, Ⅱ and Ⅲ of bladder transitional cell carcinoma were 31.8%, 62.5%, 71.8%, 80.8%, 46.7% and 83.3% respectively. The positive expression rates of Tis-T1 and T2-T4 were 41.6%, 83.3%, 73.3% and 30.0% respectively. Conclusion: P21 and cyclinD1 play an important role in bladder transitional cell carcinoma and have a negative correlation.