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用ｒａｓ癌基因产物Ｐ~（２１）单克隆抗体对１０４例乳腺良恶性病变的石蜡包埋切片进行了ＡＢＣ法免疫组织化学染色，同时对其中６０例乳腺癌新鲜组织冰冻切片进行了荧光素标记法的ＥＲ和ＰＲ检测．结果提示Ｐ~（２１）阳性表达与乳腺肿瘤的良恶性程度和患者性激素水平有关，并认为Ｐ~（２１）免疫组化检测可反映乳腺肿瘤ｒａｓ癌基因活性，表达的强弱与性激素状态和预后可能有关．
A paraffin-embedded section of benign and malignant breast lesions was stained with ABC immunohistochemical staining using ras oncogene product P21 monoclonal antibody. At the same time, 60 frozen sections of fresh breast cancer were fluorescein-labeled. Method of ER and PR detection. The results suggest that the positive expression of P21 is related to the degree of benign and malignant breast tumors and the level of sex hormones in patients. It is believed that P21 immunohistochemistry can reflect the activity of ras oncogenes in breast tumors, and the strength of expression and the status of sex hormones The prognosis may be related.