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目的:观察白斑乳膏治疗外阴营养不良的临床疗效和安全性。方法:84例鳞状上皮增生型外阴营养不良患者和80例硬化性苔癣合并鳞状上皮增生型外阴营养不良患者随机分为观察组与对照组。观察组外用白斑乳膏,对照组外用复方氟尿嘧啶乳膏,均早晚各1次,4周为1个疗程,连用3个疗程。观察2组疗效及不良反应。结果:鳞状上皮增生型外阴营养不良:观察组治愈率(85.71%)与对照组治愈率(61.90%)比较,差异有统计学意义(P<0.05);观察组总有效率(97.62%)与对照组总有效率(92.86%)比较,差异无统计学意义(P>0.05)。硬化性苔癣合并鳞状上皮增生型外阴营养不良:观察组治愈率(87.50%)、总有效率(97.50%)与对照组治愈率(65.00%)、总有效率(82.50%)比较,差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:白斑乳膏治疗鳞状上皮增生型及硬化性苔癣合并鳞状上皮增生型外阴营养不良安全、有效。
Objective: To observe the clinical efficacy and safety of white spot cream in the treatment of vulvar dystrophy. Methods: Eighty-four patients with squamous hyperplasia genital malnutrition and 80 patients with lichen sclerosus complicated with squamous hyperplasia genital malnutrition were randomly divided into observation group and control group. The observation group was treated with external leukoplakia cream and the control group with compound fluorouracil cream externally, 1 time each morning and 1 week, and 4 weeks as a course of treatment for 3 courses. The curative effect and adverse reaction of two groups were observed. Results: Squamous cell hyperplasia genital malnutrition: The cure rate of the observation group (85.71%) was significantly higher than that of the control group (61.90%) (P <0.05); the total effective rate of the observation group was 97.62% Compared with the control group (92.86%), the difference was not statistically significant (P> 0.05). Harmful lichen sclerosus with squamous hyperplasia genital malnutrition: The cure rate of the observation group (87.50%), the total effective rate (97.50%) and the control group (65.00%), the total effective rate (82.50%), the difference All were statistically significant (P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion: White spot cream treatment of squamous epithelial hyperplasia and lichen sclerosus with squamous cell hyperplasia genital malformations safe and effective.