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兰索拉唑(Lansoprazole)是新型的质子泵抑制剂。在体内以其代谢物AG-1812和AG-2000形式与壁细胞膜上的H~+-K~+-ATP酶非竞争性结合,从而作用于胃酸分泌的终末通道。由于在结构上与奥关拉唑不同,抑制胃酸分泌作用更强,对消化性溃疡的愈合、反流性食管炎的缓解,较其它抑制胃酸药物的作用更为迅速。本研究应用高压液相色谱法测定6名男性健康志愿者一次口服兰索拉唑的血药浓度,以便了解该药在我国健康人体内的药代动力学规律。
Lansoprazole is a new proton pump inhibitor. Non-competitive binding to the H ~ + -K ~ + -ATPase in the parietal cell membranes in the form of its metabolites AG-1812 and AG-2000, acting in the terminal pathway of gastric acid secretion. Due to its different structure from the olafenzole, inhibition of gastric acid secretion stronger role in the healing of peptic ulcer, reflux esophagitis relief than other inhibitory effect of gastric acid drugs more rapidly. In this study, high-pressure liquid chromatography was used to determine the oral concentration of lansoprazole in six male healthy volunteers to understand the pharmacokinetics of the drug in healthy Chinese.