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目的评价老年稳定期慢性阻塞性肺疾病(COPD)患者的呼吸力学和炎症状态,为对稳定期 COPD 患者使用相应药物持续干预治疗提供依据。方法健康对照组老年受试者40名;COPD 患者42名,均为3个月内无发作的老年稳定期随访患者,测定其肺功能和呼吸阻力指标、呼吸驱动诸项指标、血气指标及白细胞介素(IL)-8和干扰素(IFN)-γ。结果最大吸气压(PIMAX)[(4.48±2.11])kPa 和(6.10±2.91)kPa]、最大呼气压(PEMAX)[(6.30±3.20)kPa 和(9.15±3.30)kPa]、0.1s 口腔阻断压(P_(0.1))及其校正指标、气道阻力、顺应性及血气指标,以及 IL-8和 IFN-γ在COPD 组和对照组之间差异均有统计学意义;P_(0.1)及其校正指标和气道阻力及血气指标,以及 IL-8[(218.46±91.14)ng/L和(161.85±14.40)ng/L]和 IFN-γ[(2435.82±639.92)ng/L 和(1652.40±95.08)ng/L]之间明显相关。结论老年 COPD 稳定期患者的呼吸驱动、气道阻力、气道顺应性、呼吸肌力学和体液内炎性物质方面均有明显改变,对于相对稳定的 COPD 患者也应予以持续的干预治疗。
Objective To evaluate the respiratory mechanics and inflammatory status of elderly patients with chronic obstructive pulmonary disease (COPD) in the elderly and to provide a basis for the sustained intervention of the corresponding drugs in patients with stable COPD. Methods Forty elderly subjects and 42 COPD patients were healthy elderly patients with stable intra-operative follow-up within 3 months. Their lung function and respiratory resistance, respiratory drive, blood gas and white blood cells Interleukin (IL) -8 and Interferon (IFN) -γ. Results The maximum inspiratory pressure ((4.48 ± 2.11) kPa and (6.10 ± 2.91) kPa], the maximum expiratory pressure (PEMAX) [(6.30 ± 3.20) kPa and (9.15 ± 3.30) kPa] Oral pressure (P_ (0.1)) and its corrective measures, airway resistance, compliance and blood gas indexes, as well as IL-8 and IFN-γ in COPD group and control group differences were statistically significant; P_ 0.1) and its corrective index and airway resistance and blood gas index, IL-8 [(218.46 ± 91.14) ng / L and (161.85 ± 14.40) ng / L and IFN-γ [(2435.82 ± 639.92) ng / L and (1652.40 ± 95.08) ng / L]. CONCLUSIONS: Respiratory drive, airway resistance, airway compliance, respiratory muscle mechanics and inflammatory substances in body fluids of elderly patients with stable COPD have significant changes. Patients with relatively stable COPD should also be treated with continuous intervention.