单克隆抗体可通过多种作用机制治疗肿瘤,其中诱导肿瘤细胞凋亡是主要机制之一。不同的单克隆抗体可通过3种途径诱导肿瘤细胞凋亡:通过阻断生长因子及其受体信号传导途径影响肿瘤细胞的存活和生长,同时增强联合治疗中化疗或放疗的作用;通过使相应的抗原交联启动细胞凋亡途径;通过直接作用于死亡受体导致细胞凋亡。 Monoclonal antibodies can treat tumors through a variety of mechanisms of action, of which induction of apoptosis in tumor cells is one of the major mechanisms. Different monoclonal antibodies induce tumor cell apoptosis in three ways: by blocking the growth factor and its receptor signaling pathways affecting the survival and growth of tumor cells, while enhancing the effects of chemotherapy or radiotherapy in combination therapy; The antigen cross-linking initiates the apoptotic pathway; it leads to apoptosis by acting directly on the death receptor.