论文部分内容阅读
目的对不育男性患者进行外周血染色体核型的分析,探讨染色体异常与男性不育的遗传学效应。方法按常规方法制作染色体标本,G显带,400条带水平进行不育男性患者染色体核型分析。结果受检的892例患者中,检查出染色体异常核型88例,异常检出率为9.87%。包括性染色体异常67例和常染色体异常21例,分别占受检不育男性患者的7.51%和2.35%。在所有染色体异常核型中,Klinefelter综合征的发生率最高,有24例,占异常核型的27.27%。结论染色体异常是导致男性不育的重要原因之一,染色体核型分析对不育男性患者的诊断和治疗具有重要的指导意义。
Objective To analyze the chromosomal karyotypes of peripheral blood in infertile men and to investigate the genetic effects of chromosomal abnormalities and male infertility. Methods Chromosomal specimens were prepared according to the conventional method. G banding and 400 banding were performed to analyze the karyotypes of infertile men. Results Among the 892 patients examined, 88 cases of chromosomal aberration karyotype were detected, and the abnormality detection rate was 9.87%. Including 67 cases of chromosomal abnormalities and 21 cases of autosomal abnormalities, accounting for 7.51% and 2.35% of infertile men respectively. Among all the karyotypes, the incidence of Klinefelter syndrome was the highest, with 24 cases accounting for 27.27% of the abnormal karyotypes. Conclusion Chromosomal abnormalities are one of the most important causes of male infertility. Chromosomal karyotype analysis is of great importance to the diagnosis and treatment of infertile men.