论文部分内容阅读
目的 :明确抗结核药物副反应的特点。方法 :回顾性分析武汉市结核病医院近十年抗结核治疗过程中发生的需要改变治疗方案的药物副反应发生率。结果 :1492 2例患者中 ,出现需要改变治疗方案的药物副反应 140例 ,占 0 .94% ,其中肝功能损害 6 7例 (47.9% ) ,其次为药物性皮疹 47例 (33.6 % ) ,其它副反应少见。因药物副反应死亡 2例 ,1例由 RFP引起 ,1例未明确为何种药物引起。结论 :抗结核药物副作用引致需要改变治疗方案的副反应中 ,以肝功能损害最多见 ,其次为药物性皮疹。
Objective: To clarify the characteristics of side effects of anti-TB drugs. Methods: A retrospective analysis of TB hospital in Wuhan in the last decade of anti-TB treatment need to change the treatment program of drug side effects. Results: Among the 1492 patients, 140 patients (0.94%) had adverse drug reactions that needed to be changed, including 67 (47.9%) with liver dysfunction, followed by 47 (33.6%) with drug-induced rash. Other side effects are rare. Two patients died of adverse drug reactions, one was caused by RFP, and one was not specifically identified as the cause of the drug. CONCLUSIONS: Side effects of anti-TB drugs lead to the most common liver damage, followed by drug-induced rashes, in side-effects that require treatment changes.