蓖麻毒蛋白(Ricin)虽在19世纪已受到重视和研究,但对于药理研究方面都未见系统的报道,近年来国内对蓖麻毒蛋白的分离、提纯及对实验动物肿瘤筛选等进行了研究,1977年武医附二院肿瘤科曾报道应用蓖麻毒蛋白油膏治疗恶性肿瘤取得可喜的苗头,为使蓖麻毒蛋白在临床上作进一步试用推广,我组与武汉健民制药厂协作,将该厂提供的蓖麻毒蛋白样品(小鼠LD_(50)为47.97微克/公斤),进行了蓖麻毒蛋白临床前的药理研究。初步结果如下。 Although Ricin has received attention and research in the 19th century, no systematic report has been made on pharmacological research. In recent years, Ricin has been used in the isolation and purification of ricin and its screening for experimental animal tumors. In the study, in 1977, the Department of Oncology of the Second Affiliated Hospital of Wuwei Hospital reported that ricin-containing protein ointment was used to treat malignant tumors. In order to make the ricin protein for further trial and promotion in clinical practice, our group and Wuhan Jianmin Pharmaceutical Factory In collaboration with the ricin protein sample provided by the plant (47.97 μg/kg mouse LD_50), preclinical pharmacological studies of ricin were performed. The preliminary results are as follows.