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目的探讨肌钙蛋白I(cTnI)、肌红蛋白(Mb)定量检测在心血管疾病中的临床价值。方法A组:健康对照组100例,男女各50例,平均52岁。于早晨空腹取静脉血3ml送检。B组:冠心病患者153例,男94例,女59例,于早晨空腹取静脉血3ml送检;C组:急性心肌梗死(AMI)无合并症组158例,其中男121例,女37例,年龄24～86岁,平均66岁,于胸痛发作后3h抽静脉血3ml送检。D组:AMI合并心力衰竭组146例,男118例,女28例。年龄40～84岁,平均65岁,于胸痛发作后3h临床表现为有心力衰竭症状时抽静脉血3ml送检。A、B、C、D组全部采用全自动微粒子化学发光分析仪定量检测cTnI、Mb。结果A组cTnI浓度为(0.27±0.18)μg/L,Mb浓度为(42±21)μg/L;B组cTnI浓度为(0.45±0.17)μg/L,Mb浓度为(46±20)μg/L,A组与B组差异无统计学意义(P=0.52,P>0.5);C组cTnI浓度为(16.71±14.19)μg/L,Mb浓度为(522±392)μg/L;D组cTnI浓度为(25.01±19.12)μg/L,Mb浓度为(936±712)μg/L;B组与C、D组比较差异具有统计学意义(P=0.000,P<0.01);C组与D组比较差异具有非常显著性的意义(P=0.002,P<0.01)。结论cTnI、Mb对冠心病患者继发急性心肌梗死有很高的诊断价值,对有胸痛症状的冠心病患者检测cTnI、Mb可早期诊断AMI,及时溶栓和治疗。从C组和D组的结果来看,D组cTnI、Mb比C组显著增高,因此,当cTnI浓度达到(25.01±19.12)μg/L,Mb浓度达到(936±712)μg/L时,可合并心力衰竭。
Objective To investigate the clinical value of quantitative detection of troponin I (cTnI) and myoglobin (Mb) in cardiovascular diseases. Method A group: 100 healthy control group, 50 men and women, average 52 years old. In the morning fasting venous blood 3ml submission. Group B: 153 patients with coronary heart disease, 94 males and 59 females, in the morning fasting venous blood 3ml for inspection; C group: acute myocardial infarction (AMI) without complications in 158 cases, including 121 males and 37 females Cases, aged 24 to 86 years old, average 66 years old, 3 hours after the onset of chest pain venous blood 3ml submission. Group D: AMI with heart failure group of 146 cases, 118 males and 28 females. Aged 40 to 84 years old, average 65 years old, 3 hours after the onset of chest pain clinical manifestations of heart failure symptoms when pumping venous blood 3ml submission. A, B, C, D group using automatic particle chemiluminescence quantitative detection of cTnI, Mb. Results The concentration of cTnI in group A was (0.27 ± 0.18) μg / L and the concentration of Mb was (42 ± 21) μg / L in group A; the concentration of cTnI in group B was (0.45 ± 0.17) μg / / L, there was no significant difference between group A and group B (P = 0.52, P> 0.5). The concentration of cTnI in group C was (16.71 ± 14.19) μg / L and the concentration of Mb was (522 ± 392) (25.01 ± 19.12) μg / L for cTnI and (936 ± 712) μg / L for Mb respectively. There was significant difference between group B and groups C and D (P = 0.000, P <0.01) Compared with the D group has a significant difference (P = 0.002, P <0.01). Conclusions cTnI and Mb have high diagnostic value in patients with coronary heart disease secondary to acute myocardial infarction. To detect cTnI and Mb in patients with chest pain and coronary heart disease, early diagnosis of AMI, timely thrombolysis and treatment can be performed. From the results of groups C and D, cTnI and Mb in group D were significantly higher than those in group C. Therefore, when cTnI reached (25.01 ± 19.12) μg / L and Mb reached (936 ± 712) μg / L, Can be combined heart failure.