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目的评价降钙素原(PCT)、C-反应蛋白(CRP)联合检测在革兰阴性菌致病的老年下呼吸道感染疾病中的诊断价值。方法回顾分析87例经确诊的下呼吸道感染的老年患者,依据感染类型分成3组,并与健康志愿者对照,比较不同感染类型的患者PCT、CRP水平差异,并利用ROC曲线分析PCT、CRP的诊断价值。结果细菌感染组、非细菌感染组的PCT、CRP水平与对照组比较差异具有统计学意义(P<0.05),其中革兰阴性细菌感染组的PCT水平明显高于革兰阳性细菌感染组,差异具有统计学意义(P<0.01)。绘制革兰阴性组和对照组的ROC曲线,计算出PCT和CRP的曲线下面积分别为0.966、0.928。结论 PCT、CRP检测应用于革兰阴性菌致病的老年下呼吸道感染疾病有明确的诊断价值,且PCT的诊断价值优于CRP。
Objective To evaluate the value of combined detection of procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis of lower respiratory tract infections in elderly patients with Gram-negative bacteria. Methods Retrospective analysis of 87 elderly patients with confirmed lower respiratory tract infection was divided into 3 groups according to the type of infection and compared with healthy volunteers to compare PCT and CRP levels in patients with different types of infection. ROC curves were also used to analyze PCT, CRP Diagnostic value. Results The levels of PCT and CRP in bacterial infection group and non-bacterial infection group were significantly different from those in control group (P <0.05). The PCT level in Gram-negative bacteria group was significantly higher than that in Gram-positive bacteria group, With statistical significance (P <0.01). The ROC curves of Gram-negative and control groups were plotted, and the area under the curve of PCT and CRP was calculated to be 0.966 and 0.928, respectively. Conclusions The detection of PCT and CRP in patients with Gram-negative bacterial pathogenic lower respiratory tract infection have clear diagnostic value, and the diagnostic value of PCT is better than that of CRP.