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目的 :探讨尿液中内皮素 1(ET 1)在兔不全梗阻性膀胱中的变化和意义。 方法 :运用放射免疫分析技术对 10只成年雄性新西兰白兔不全梗阻性膀胱 (实验组 ,分为梗阻 3周组及梗阻 6周组 )及 10只同龄雄性新西兰白兔无梗阻性膀胱 (对照组 ,分为术后 3周组及术后 6周组 )兔尿液中ET 1进行研究。 结果 :尿液中ET 1含量实验组较对照组明显升高 ,实验组梗阻 3周组与对照组术后 3周组及实验组梗阻 6周组与对照组术后 6周组比较均差异显著 (P <0 .0 1) ,实验组梗阻 3周组与 6周组比无显著差异 (P >0 .5 ) ,对照组术后 3周组与术后 6周组比无显著差异 (P >0 .5 )。 结论 :在兔不全梗阻性膀胱中 ,ET 1对膀胱壁结构改变及功能紊乱具有一定作用 ,尿液中ET 1升高可作为诊断膀胱出口梗阻的一个重要参数。
Objective: To investigate the changes and significance of endothelin 1 (ET 1) in the urine of incomplete obstructive bladder in rabbits. Methods: Radioimmunoassay was performed on 10 adult male New Zealand white rabbits with incomplete obstructive bladder (experimental group, 3 weeks obstruction group and 6 weeks obstruction group) and 10 male New Zealand white rabbits without obstruction bladder (control group , Divided into 3 weeks after surgery and 6 weeks after surgery) rabbit urine ET 1 study. Results: The content of ET 1 in urine in experimental group was significantly higher than that in control group. There was significant difference in experimental group between 3 weeks after operation and 3 weeks after operation in obstructive group and 6 weeks after operation in obstructive 6 weeks group (P <0.01). There was no significant difference between the 3-week group and 6-week group in the experimental group (P> 0.05), but there was no significant difference between the 3-week group and the 6-week group > 0 .5). Conclusion: In the incomplete obstructive bladder of rabbits, ET 1 plays a role in the structural changes and dysfunction of the bladder wall. Increasing of ET 1 in urine can be used as an important parameter to diagnose bladder outlet obstruction.