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目的观察适形放疗联合化疗同步与序贯治疗中晚期非小细胞肺癌的临床疗效。方法选择不能手术的中晚期非小细胞肺癌(NSCLC)患者100例,随机分成同步组和序贯组各50例。适形放疗采用三维适形放疗(3D-CRT)和调强放疗(IM-RT)方法,化疗方案为盖诺+顺铂(NP方案)。结果治疗总有效率比较(CR+PR):同步组78%,序贯组46%,两组比较差异有显著性(P<0.05);生存率(Kaplan-Meier法)比较:同步组1年生存率为71.2%,序贯组为50.3%,两组比较差异有显著性(P<0.05);两组病人均能耐受治疗中的不良反应。结论同步组的近期疗效明显优于序贯组,能提高患者的一年生存率。该方法是治疗中晚期非小细胞肺癌较好的方案。
OBJECTIVE: To observe the clinical efficacy of simultaneous and sequential treatment with conformal radiotherapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Methods A total of 100 patients with non-surgical advanced non-small cell lung cancer (NSCLC) were randomly divided into synchronous group and sequential group (50 cases). Conformal radiotherapy uses three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IM-RT) methods. The chemotherapy regimen is genotol + cisplatin (NP regimen). Results The total effective rate of treatment (CR+PR) was 78% in synchronous group and 46% in sequential group. There was significant difference between the two groups (P<0.05); survival rate (Kaplan-Meier method) comparison: synchronization group 1 year The survival rate was 71.2% and 50.3% in the sequential group. There was a significant difference between the two groups (P<0.05). Both groups of patients could tolerate the adverse reactions during treatment. Conclusions The short-term efficacy of the synchronous group is significantly better than that of the sequential group, which can improve the patient’s one-year survival rate. This method is a better treatment for advanced non-small cell lung cancer.