论文部分内容阅读
为了评价老年患者心肌梗塞后长期口服抗凝剂的危险性,作者详细研究了878例老年患者在双盲法试验期间所观察到的出血性并发症。这些患者均已用过抗凝剂治疗6个月～10年以上,平均6年。半数患者采用安慰剂代替抗凝剂,另一半则继续用抗凝剂治疗。所有患者随访2年,总危险期为827年。结果共发生颅内并发症32次,颅外出血性并发症116次。颅内并发症中抗凝剂(AC)组占12次,安慰剂组20次,而肯定有颅内出血者分别为8次和1次(P=0.04)。2例有硬膜下血肿的AC组患者康复。在21例颅内并发症未恢复的患者中,
To assess the risk of long-term oral anticoagulation in elderly patients after myocardial infarction, the authors studied in detail the hemorrhagic complications observed in 878 elderly patients during the double-blind trial. These patients have been treated with anticoagulants for 6 months to 10 years or more, an average of 6 years. Half of the patients took placebo instead of anticoagulants and the other half continued to use anticoagulants. All patients were followed up for 2 years with a total risk of 827 years. Results A total of 32 intracranial complications and 116 extracranial hemorrhagic complications occurred. The incidence of intracranial complications was 12 for the anticoagulant (AC) group and 20 for the placebo group, and 8 and 1 for intracranial hemorrhage, respectively (P = 0.04). Two patients with AC subdural hematoma recovered. Among the 21 patients with intracranial complications who did not recover,