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目的 探索胆石病家族聚集性及遗传方式。方法 采用遗传流行病学病例对照研究方法 ,对 317个家系 ( 138个胆石病先证家系和 179个对照家系 )进行研究。结果 病例组一级亲属总的胆石病患病率为 2 .60 % ,显著高于对照组的 1.2 9% ( χ2 =4.78,P =0 .0 2 88) ;分离比为显著低于 0 .2 5 ,不符合单基因遗传疾病的特征 ;遗传度估算显示 ,该病一级亲属中 ,遗传度为2 1.80 % ,其中男性亲属的遗传度为 36.34% ,显著高于女性亲属的 14 .15 %。结论 在胆石病的病因中 ,遗传因素起一定作用 ,尤其对男性作用更为明显。
Objective To explore the family aggregation and inheritance of gallstone disease. Methods Genetic epidemiological case control study was used to study 317 families (138 proband families with gallstone disease and 179 control families). Results The prevalence of total gallstone disease in the first-degree relatives of the case group was 2.6%, which was significantly higher than that of the control group (1.29%) (χ2 = 4.78, P = 0.028); the segregation ratio was significantly lower than 0. 25 is not consistent with the characteristics of a single-gene inherited disease; heritability estimates indicate that the first-degree relatives of the disease have a heritability of 2 1.8%, of which the heritability of male relatives is 36.34%, which is significantly higher than that of female relatives. %. Conclusion In the etiology of gallstone disease, genetic factors play a role, especially for males.