论文部分内容阅读
本文作者利用小鼠生殖细胞对低剂量辐射(50mGy)X射线和低浓度化学物质(MMC,H_2O_2,CP)之间的交叉耐受性作了研究。首次证明在整体条件下的生殖细胞中,无明显毒性剂量的MMC(0.1和0.5mg/kg)和H_2O_2(0.02和0.05mol/L)均可诱导抗1.5GyX射线诱发的生殖细胞染色体损伤;并且50mGy射线也可诱导抗大剂量MMC(3.0和5.0mg/kg)和H2O2(0.5和1.0mol/L)诱发的生殖细胞染色体损伤。与此相反,低浓度的烷化剂环磷酰胺(0.5和1.0mg/kg)不能诱导抗电离辐射诱发生殖细胞染色体损伤的适应性反应;低剂量辐射也不能诱导抗大剂量环磷酰胺(25和40mg/kg)的适应性反应,这些结果说明:辐射与DNA交联剂和DNA氧化性损伤因子之间存在着广泛低剂量诱导相互耐受性的适应性反应,而与产生DNA烷基化损伤的烷化剂之间不存在着交叉抗性。
The authors used mouse germ cells to study the cross-tolerance of low dose radiation (50 mGy) X-rays and low concentrations of chemicals (MMC, H 2 O 2, CP). It was first demonstrated that MMC (0.1 and 0.5 mg / kg) and H 2 O 2 (0.02 and 0.05 mol / L), respectively, were able to induce resistance to 1.5 Gy X-rays in germ cells under general conditions Of germ cell chromosome damage; and 50mGy ray can also induce high-dose MMC (3.0 and 5.0mg / kg) and H2O2 (0.5 and 1.0mol / L) induced germ cell chromosome damage. In contrast, low concentrations of alkylating agents cyclophosphamide (0.5 and 1.0 mg / kg) failed to induce adaptive responses to chromosomal damage induced by ionizing radiation; germ cells also failed to induce high doses of cyclophosphamide (25 and 40 mg / kg), these results suggest that there is a wide range of low dose-induced adaptive responses between radiation and DNA crosslinkers and DNA oxidative damaging factors, There is no cross-resistance between alkylated damaged alkylating agents.