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目的 :通过复方核酸颗粒剂的研制及临床疗效观察 ,确定其药理作用。方法 :采用质控标准 ,制备药品 ;按临床诊断标准筛选22例冠心病、稳定型心绞痛伴有高血脂的患者 ,进行疗效观察。结果 :(1)心绞痛临床症状改善情况 :显效22 7 % ,有效68 2 % ,无效9 0 % ;(2)血脂分析 :胆固醇及甘油三酯用药后均有显著改善 (P<0 05及P<0 01)。结论 :复方核酸颗粒剂有显著的抗冠心病、心绞痛及降血脂作用。
OBJECTIVE: To determine the pharmacological effects of compound nucleic acid granules by observing its clinical efficacy. Methods: Quality control standards were used to prepare medicines. According to clinical diagnostic criteria, 22 patients with coronary heart disease and stable angina with hyperlipidemia were screened, and the curative effect was observed. Results: (1) The improvement of clinical symptoms of angina pectoris was markedly improved in 22 7%, effective 68 2% and ineffective 90%. (2) Blood lipid analysis: Both cholesterol and triglyceride were significantly improved (P <0.05 and P <0 01). Conclusion: Compound nucleic acid granules have significant anti-coronary heart disease, angina pectoris and hypolipidemic effect.