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9月16日,中科院大连化物所周永贵研究员带领科手性合成研究团队在催化去外消旋化研究工作中取得新进展,成功实现了以四氢异喹啉为核心骨架的二级胺、三级胺的催化去外消旋化。相关研究成果以“Concise Redox De racemization of Secondary and Te rtiary Amines with a Tetrahyd roisoquinoline Core via a Nonenzymatic Process”为题发表在《美国化学会志》上。对外消旋混合物进行手性拆分目前仍然是实际生产中获得手性产品的最主要方法。然而拆分
On September 16, the research team of chiral synthesis led by Zhou Yonggui, researcher of CAS Institute of Chemistry and Materials, CAS, made new progresses in the catalytic research on racemization. The secondary amine with tetrahydroisoquinoline as the core skeleton and the tri Catalytic elimination of racemization of the amine. Relevant research results in the “Concise Redox De Racemization of Secondary and Tertiary Amines with a Tetrahydropisolateoline Core via a Nonenzymatic Process” in the title published in the “Journal of the American Chemical Society”. Chiral resolution of racemic mixtures is still the most important method for obtaining chiral products in actual production. However split