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目的 比较α－干扰素与卡介苗、丝裂霉素膀胱灌注预防表浅膀胱癌术后复发的疗效及副作用。方法将７３例表浅膀胱癌术后的患者随机分成３组，分别用α－干扰素、卡介苗和丝裂霉素进行膀胱灌注。结果３组中不同临床分期及病理分级的各组之间术后 ２年的复发率无显著性差异（ Ｐ＞ ０． ０５），α－干扰素组仅 １例出现膀胱刺激症状较其他 ２组有非常显著性差异（ Ｐ＜ ０． ０１）。未观察到其他副作用。结论 α－干扰素膀胱灌注预防表浅膀胱癌术后复发的疗效与卡介苗和丝裂霉素相近，其最大优点在于可经尿道直接注入和副作用少。
Objective To compare the curative effect and side effects of intravesical instillation of α-interferon and BCG and mitomycin in the prevention of postoperative recurrence of superficial bladder cancer. Methods Seventy-three patients with superficial bladder cancer were randomly divided into three groups, and received intravesical instillation of α-interferon, BCG and mitomycin respectively. Results There were no significant differences in recurrence rates between the two groups (P> 0.05) in all groups with different clinical stage and pathological grading in the 3 groups. Only 1 of the interferon-alpha groups showed bladder irritation symptoms compared with the other 2 groups There was a very significant difference (P <0.01). No other side effects were observed. Conclusion The efficacy of intravesical instillation of α-interferon in preventing postoperative recurrence of superficial bladder cancer is similar to that of BCG and MMC. The biggest advantage is that it can be directly injected through the urethra with less side effects.