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本研究应用沙门氏菌-微粒体试验(Ames试验)和SOS显色试验测试各种丁烯酸的遗传毒性。此外,用小鼠微核试验测试(Z)-2-氯-3-二氯甲基-4-氧化丁烯酸(Mx)。试验结果表明,无S-9活化Mx,其还原型(Z)-2-氯-3-二氯甲基-4-羟丁基-2-烯醇酸(red-Mx)和同分异构体(E)-2-氯-3-二氯甲基-4-氧化丁烯酸(EMx)在AMes试验中均具有诱变性。Mx对菌株TA 100具有强诱变性,自发回变数约6200/nmole。对TA98和TA97有轻度诱变性。Red-Mx对TA 100和TA97
In this study, the genotoxicity of various crotonic acid was tested by Salmonella microsomal test (Ames test) and SOS colorimetric test. In addition, (Z) -2-chloro-3-dichloromethyl-4-butenoic acid (Mx) was tested using the mouse micronucleus test. The experimental results show that, without S-9 activated Mx, its reduced (Z) -2-chloro-3-dichloromethyl-4-hydroxybutyl 2-enol (red-Mx) and isomeric The (E) -2-chloro-3-dichloromethyl-4-oxo-crotonic acid (EMx) is mutagenic in the AMes test. Mx has a strong mutagenicity on strain TA 100, with a spontaneous return variable of about 6200 / nmole. TA98 and TA97 mild mutagenicity. Red-Mx to TA 100 and TA97