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目的探讨2型糖尿病患者空腹及馒头餐后血浆中胰高血糖素水平变化及意义。方法采用放射免疫法对140例2型糖尿病患者进行空腹及馒头餐后血浆胰高血糖素、血清胰岛素水平进行检测,并对二者不同时相结果进行比较。结果糖尿病患者空腹及餐后各时相胰高血糖素偏高比例均明显高于胰岛素水平低下患者比例(P<0.05)。糖尿病患者空腹及餐后各时相胰高血糖素偏高者百分比与胰岛素水平低下者百分比分别为:空腹胰高血糖素为60%,(150±33)pg/ml,P<0.01,胰岛素为4.29%,(4.4±0.8)mIU/L,P<0.01;餐后1h胰高血糖素为91.86%,(154±37)pg/ml,P<0.01,胰岛素为72.86%,(20.2±5.9)mIU/L,P<0.01;餐后2h胰高血糖素为91.43%,(144±31)pg/ml,P<0.01,胰岛素为38.57%,(15.1±3.4)mIU/L,P<0.01;餐后3h胰高血糖素为71.43%,(141±30)pg/ml,P<0.01,胰岛素2.86%,(4.1±0.74)mIU/L,P<0.01。结论胰高血糖素异常升高是导致2型糖尿病患者血糖偏高的重要因素,检测胰高血糖素水平有助于临床准确判断糖尿病患者病情。
Objective To investigate the changes and significance of postprandial glucagon in fasting and steamed bread in type 2 diabetic patients. Methods The fasting and postprandial plasma glucagon and serum insulin of 140 type 2 diabetic patients were detected by radioimmunoassay, and the results of the two phases were compared. Results The fasting and post-prandial phases of glucagon in diabetic patients were significantly higher than those in patients with low insulin levels (P <0.05). The percentages of fasting and postprandial high glucagon in each phase and the percentage of low insulin were as follows: fasting glucagon 60%, (150 ± 33) pg / ml, P <0.01, insulin 4.29% and (4.4 ± 0.8) mIU / L respectively, P <0.01; 1h postprandial glucagon was 91.86%, (154 ± 37) pg / ml, P <0.01; insulin was 72.86%, (20.2 ± 5.9) (P <0.01), insulin was 38.57%, (15.1 ± 3.4) mIU / L, P <0.01; P <0.01) The postprandial 3 h glucagon was 71.43%, (141 ± 30) pg / ml, P <0.01, insulin 2.86%, (4.1 ± 0.74) mIU / L, P <0.01. Conclusion The abnormal increase of glucagon is an important factor leading to the high blood sugar in patients with type 2 diabetes. Detecting glucagon level is helpful to accurately diagnose the condition of diabetic patients.