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45例直肠癌病人(93.2%为 Dukes B 及 C 期),术前经肛门给予5-Fu 栓剂10日左右,平均总剂量7545mg。从临床、病理表现进行观察,发现病人对药物耐受性好。切除标本光镜观察见癌细胞呈中度至明显变性或坏死者占67.5%。癌组织和局部淋巴结内5-Fu 浓度测定分别为2.48±1.07及3.97±1.32μg/g,5-Fu 栓剂对直肠癌有一定效果。在不具备放疗条件时可以作为术前化疗手段。
Forty-five patients with rectal cancer (93.2% for Dukes B and C stage) received suppository 5-Fu suppository preoperatively for 10 days with an average total dose of 7545 mg. Observed from the clinical and pathological findings, it was found that the patient is well tolerated by the drug. Light microscopy of resected specimens revealed that 67.5% of cancer cells showed moderate to significant degeneration or necrosis. The concentrations of 5-Fu in cancer tissues and local lymph nodes were 2.48±1.07 and 3.97±1.32μg/g, respectively. 5-Fu suppository has a certain effect on rectal cancer. In the absence of radiotherapy conditions can be used as preoperative chemotherapy.