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应用家兔急性胰腺炎(AP)模型证明,YHI(元胡注射液)及HHI-I(活血化瘀注射液Ⅰ号)合并静脉注射,有增加家兔存活时间和五天存活率的趋势(对照组33.3%;治疗组83.3%)。药物使AP动物血清淀粉酶明显下降。胰组织微循环明显改善,并使重型AP严重性的指标白细胞介素-6水平明显低于对照组。病理检查结果也显示白细胞浸润、脂肪坏死、出血等指标均较对照组为轻。实验提示,YHI与HHI-I联合应用对家兔重型AP有保护作用。
Application of rabbit acute pancreatitis (AP) model proved that YHI (Yuanhu injection) and HHI-I (Huoxuehuayu injection Ⅰ) combined with intravenous injection, there is an increase of rabbit survival time and five-day survival trend 33.3% in control group; 83.3% in treatment group). Drugs AP APS serum amylase decreased significantly. The microcirculation of pancreatic tissue was significantly improved, and the level of interleukin-6, a marker of severe AP severity, was significantly lower than that of the control group. Pathological examination also showed leukocyte infiltration, fat necrosis, bleeding and other indicators were lighter than the control group. Experiments suggest that, YHI and HHI-I joint application of heavy AP in rabbits have a protective effect.