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目的:探讨前列地尔对心力衰竭患者心脏功能和心室重构的影响。方法:将2013年8月至2015年5月广东省潮州市饶平县华侨医院心内科收治的心力衰竭患者80例随机分为对照组和研究组各40例,两组年龄、病程、原发病和心室率等差异无显著性(P>0.05);对照组按常规治疗,研究组在对照组治疗的基础上加用前列地尔10 ug/次,每日1次,持续10-14 d,2周后比较两组治疗前后心脏功能和心室重构的变化。结果:与对照组相比,治疗后研究组的左室舒张末期内径缩小,左室射血分数增高,6 min步行距离延长,静息心率显著减慢(P均<0.01);研究组总有效率高(P<0.01),且无严重并发症发生。结论:应用前列地尔治疗心力衰竭安全、有效,能明显改善心脏功能和心室重构,值得临床推广应用。
Objective: To investigate the effect of prostaglandin on heart function and ventricular remodeling in patients with heart failure. Methods: From August 2013 to May 2015, 80 cases of heart failure admitted to Huaqiao Hospital of Overseas Chinese Hospital of Raoping County, Chaozhou City, Guangdong Province were randomly divided into control group and study group, 40 cases each. The age, course of disease, (P> 0.05). The control group was treated routinely. The study group was given alprostadil 10 ug once daily for 10-14 days Two weeks later, the changes of cardiac function and ventricular remodeling before and after treatment were compared. Results: Compared with control group, left ventricular end-diastolic diameter, left ventricular ejection fraction increased, walking distance extended 6 min and resting heart rate decreased significantly after treatment (P <0.01) High efficiency (P <0.01), and no serious complications occurred. Conclusion: The application of alprostadil in the treatment of heart failure is safe and effective, and can significantly improve cardiac function and ventricular remodeling. It is worthy of clinical application.