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通过大鼠阴道混合感染金葡球菌、大肠杆菌和淋球菌的动物模型．以阴道分泌物的细菌转阴率和阴道粘膜炎症的治愈程度为指标，观察诺氟沙星栓4个剂量组的治疗效果，结果显示：量一效关系密切，相关系数（r）检验，P值均＜0．01。诺氟沙星对大肠杆菌、金葡球菌和淋球菌的ED50（95％可信限）分别为12．50（10．27～15．21）、15．48（13．11～18．29）和9．39（7．68～11．49）mg／kg。
Animal models of Staphylococcus aureus, Escherichia coli and Neisseria gonorrhoeae infected by vaginal mixing in rats. Vaginal secretions of the bacteria negative rate and the degree of cure of vaginal mucosal inflammation as an indicator to observe the norfloxacin suppository treatment effect of the four dose groups, the results showed that: the amount of the effect of a close relationship, correlation coefficient (r) test, P Values <0.01. The ED50 (95% confidence interval) of norfloxacin against Escherichia coli, Staphylococcus aureus and Neisseria gonorrhoeae were 12.50 (10.27 ~ 15.21), 15.48 (13.11 ~ 18.29) And 9.39 (7.68 ~ 11.49) mg / kg.