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目的探索慢性苯暴露与MPO-463G/A基因位点多态性的关系。方法根据《国家职业卫生标准》,选择苯职业接触者78例和对照组82例,采用PCR-RFLP法检测深圳市龙华区苯暴露工种人群血样中MPO-463G/A基因型,同时检查血常规。结果苯职业接触组与对照组工作人员的白细胞、红细胞和血小板计数低下率比较差异均无统计学意义(均P>0.05);MPO-463G/A基因型在苯职业接触者组以及对照组分布差异有统计学意义(χ2=15.674,P<0.01),野生型G/G对于苯职业接触者相对于突变型G/A或A/A的相对危险度为3.488,95%CI为1.82~6.70。结论在相似的环境苯暴露中,野生型G/G型的个体更易发生慢性苯中毒。
Objective To explore the relationship between chronic benzene exposure and MPO-463G / A polymorphism. Methods According to the National Occupational Health Standard, 78 workers with benzene occupational exposure and 82 control subjects were enrolled in this study. The genotypes of MPO-463G / A in blood samples from benzene exposed workers in Longhua District of Shenzhen City were detected by PCR-RFLP. . Results There were no significant differences in the leucocyte, erythrocyte and platelet count rates between benzene occupational exposure group and control group (all P> 0.05). The distribution of MPO-463G / A genotype in benzene occupational exposure group and control group The difference was statistically significant (χ2 = 15.674, P <0.01). The relative risk of wild-type G / G for benzene occupational exposure relative to mutant G / A or A / A was 3.488, and the 95% CI was 1.82-6.70 . Conclusions In similar environmental benzene exposures, individuals with wild type G / G are more likely to develop chronic benzene poisoning.