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目的探讨血浆内皮素（Endothelins，ET）在实验性脑出血大鼠急性期中的作用，初步分析其作用机制；方法建立大鼠脑出血模型，采用层析柱法动态测定急性期ET含量，电镜下观察脑组织形态学改变；结果实验组与对照组各观察点比较，4小时点差异显著（P＜0．05），12小时与7天点差异非常显著（P＜0．01），3天与1天点差异极显著（P＜0．001）；组内比较12小时点，ET含量最高，以后逐渐下降，此时脑组织神经元损害最严重；结论ET可能参与了脑组织出血的病理生理演变过程，是一个新的相关因素。
Objective To investigate the role of endothelin (ET) in the acute phase of experimental intracerebral hemorrhage in rats and its mechanism of action. Methods The rat model of intracerebral hemorrhage was established. The content of ET in the acute phase was determined by chromatographic column. The morphological changes of the brain tissue were observed. Results The difference between the experimental group and the control group was significant at 4 hours (P <0.05), and at 12 and 7 days (P <0.01) (P <0.001). Compared with 12-hour group, ET content was the highest in the group and then gradually decreased. At this time, the damage of neurons in brain tissue was the most serious. Conclusion ET may be involved in the pathological changes of brain tissue hemorrhage Physiological evolution is a new relevant factor.