近年来国内外文献报导了增殖细胞的核抗原ki—67。Gerdes等用何杰金氏细胞系L—428细胞的粗提核成分制备了ki—67单克隆抗体用于检测于处于增殖周期人类细胞核抗原,现已证实ki—67阳性反应仅存在于增殖细胞核,其表达与细胞增殖高度相关。同时见有报导ki—67抗原表达和DNA流式细 In recent years, domestic and foreign literature reported proliferating cell nuclear antigen ki-67. Gerdes and other Hodgkin cell line L-428 cell crude extract nuclear component ki-67 monoclonal antibody was used to detect in the proliferative cycle of human nuclear antigen, it has been confirmed that ki-67 positive reaction exists only in the proliferating cell nucleus , Its expression is highly correlated with cell proliferation. See also ki-67 antigen expression and DNA flow fine