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目的评价孕妇产前应用乙型肝炎免疫球蛋白(hepatitis B immune globulin,HBIG)阻断乙型肝炎病毒(hepatitis B virus,HBV)宫内传播的效果。方法查阅国内外有关孕妇产前使用HBIG阻断宫内传播的研究,收集出生及1岁婴儿乙肝表面抗原(hepatitis B surface antigen,HBsAg)检测情况,通过Stata 12.0软件进行Meta分析,获得合并RR值。结果新生儿随机效应模型干预组与对照组合并RR值为0.37,95%CI:0.23~0.61;1岁婴儿随机效应模型干预组与对照组合并RR值为0.48,95%CI:0.27~0.84。结论应用HBIG 200 IU可以有效阻断乙肝病毒的宫内传播。
Objective To evaluate the effect of prenatal hepatitis B immune globulin (HBIG) on preventing the intrauterine transmission of hepatitis B virus (HBV) in pregnant women. Methods The study on the intrauterine transmission of pregnant women using HBIG during prenatal and postnatal period was investigated. The detection of hepatitis B surface antigen (HBsAg) in infants and 1-year-old infants was collected. Meta-analysis was performed with Stata 12.0 software to obtain the combined RR . Results The RR of intervention group was 0.37 and 95% CI: 0.23-0.61 respectively. The RR of intervention group was 0.48 and 95% CI was 0.27-0.84. Conclusion HBIG 200 IU can effectively block the intrauterine transmission of hepatitis B virus.