巨噬细胞集落刺激因子(M-CSF)是一种单核巨噬细胞特异性的生长因子,以往的研究集中在其对单核巨噬细胞系统生长、分化的调节上。自从建立M-CSF基因完全缺无的og/op小鼠模型以来,其在生殖医学中的作用逐渐受到关注。但目前对M-CSF在胚胎植入过程中的生理作用仍所知甚少,并有许多有争议的报道。本文对近年有关M-CSF在胚胎植入过程中作用的研究发现进行简要介绍。 Macrophage colony-stimulating factor (M-CSF) is a kind of monocyte-macrophage-specific growth factor. Previous studies have focused on the regulation of monocyte-macrophage system growth and differentiation. Since the establishment of the og / op mouse model of M-CSF gene deficiency, its role in reproductive medicine has drawn increasing attention. However, little is known about the physiological role of M-CSF in embryo implantation and many controversial reports have been reported. In this paper, the recent findings on the role of M-CSF in embryo implantation are briefly introduced.