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目的 探讨新疆维吾尔族 (维族 )、汉族妇女宫颈糜烂与单纯疱疹病毒 (HSV)活动感染的关系。方法 用酶联免疫吸附实验 (ELISA)方法对 79例维族、12 8例汉族不同程度 (Ⅰ、Ⅱ、Ⅲ度 )宫颈糜烂病人和 2 9例维族、41例汉族正常对照进行血清HSV 1型和HSV 2型特异性IgM、IgG抗体检测 ,同时用聚合酶链反应 (PCR)检测上述病例和对照宫颈分泌物中HSV DNA。结果 维、汉族不同程度宫颈糜烂病人HSV 1IgM阳性率 (活动感染率 )分别为 2 7 8%和 2 6 8% ,正常对照维、汉族分别为 2 0 7%和 2 1 9% ,民族间、病例组和正常对照组间以及不同程度糜烂组间HSV 1活动感染率差异无显著 (P >0 0 5 )。维、汉族病例组HSV 2活动感染率分别为36 7%和 32 0 % ,显著高于正常对照组 13 8%和 9 8% (P <0 0 5 ) ,而维、汉族间不同程度糜烂组间差异无显著性 (P >0 0 5 )。维、汉族病例组HSV 2原发感染率为 16 5 %和 13 3% ,宫颈分泌物HSV DNA检出率维、汉族病例组分别为 36 0 %和 31 2 % ,显著高于正常对照组 13 8%和 7 3% (P <0 0 5 )。在病例组中 ,其HSV DNA检出率随糜烂程度的加重而升高。结论 新疆维、汉族妇女宫颈糜烂的产生和HSV 2活动感染有关。
Objective To investigate the relationship between cervical erosion and herpes simplex virus (HSV) infection among Uyghur (Uygur) and Han women in Xinjiang Uygur Autonomous Region. Methods Serum samples of HSV type 1 and type 2 were collected from 79 cases of Uygur, 128 cases of cervical erosion of different degree (Ⅰ, Ⅱ, Ⅲ degrees), 29 cases of Uygur and 41 cases of normal Han from Han nationality by enzyme-linked immunosorbent assay (ELISA) HSV 2 type specific IgM, IgG antibody detection, while using polymerase chain reaction (PCR) detection of HSV DNA in the case and control cervical secretions. Results The positive rate of HSV 1IgM in patients with cervical erosion was 18.8% and 26.8% respectively in the Han and Han nationalities, and 20.7% and 21.9% in the normal controls and Han nationality respectively. There was no significant difference in the infection rate of HSV 1 between the case group and the normal control group and the different degrees of erosion groups (P> 0.05). The infection rates of HSV 2 in the cases of Victoria and Han were 36.7% and 32.0% respectively, significantly higher than those in the control group (13.8% and 98%, P <0 05) There was no significant difference between the two groups (P> 0.05). The primary infection rates of HSV 2 in Victoria and Han cases were 16.5% and 13.3%, respectively. The detection rate of HSV DNA in cervix and Han was 36.0% and 31.2% respectively, which was significantly higher than that of the normal control group 8% and 73% (P <0 05) respectively. In the case group, the detection rate of HSV DNA increased with the exacerbation of erosions. Conclusion The incidence of cervical erosion in Xinjiang Uygur and Han women is related to HSV 2 activity.