近十年来,对于将反应性高聚物与具有生物活性物质如多肽、酶、抗原、抗体及核酸等之间通过共价偶联的反应而得到固定化酶和固定化免疫吸附剂等的研究已有较多的报道。在反应性高聚物中,关于分子中含有N-丁二酰亚胺活性酯(简称HOSu活性酯)的烯类单体的合成及聚合报道较少。Ferruti等首先合成了甲基丙烯酸和丙烯酸的HOSu活性酯单体及其聚合物,并研究了此反应性聚合物与胺化物的化学反应。Batz等及Winston等分别研究了 In recent ten years, research on obtaining immobilized enzymes and immobilized immunoadsorbents by reaction of covalent coupling between reactive polymers and bioactive substances such as polypeptides, enzymes, antigens, antibodies and nucleic acids, etc. There have been more reports. Among the reactive polymers, fewer reports on the synthesis and polymerization of vinyl monomers containing N-succinimide active ester (HOSu active ester) in the molecule. Ferruti et al first synthesized methacrylic acid and acrylic HOSu active ester monomer and its polymer, and studied the reactive polymer and amine chemical reaction. Batz et al. And Winston et al