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感染是引起新生儿疾病及死亡的重要原因,在国内新生儿感染更较常见。要降低新生儿感染的病死率,关键在于正确地早用抗微生物药物。如何才能用药正确,应先了解药物动力学在新生儿的特点。新生儿期药物动力学的特点新生儿身体各部分的生理与代谢过程一直在不停的改变,不但不能将成人的药物动力学的资料应用于新生儿,也不能将同样的药物剂量及用法应用于出生后1天的早产儿及14天的足月新生儿,因为二者的肝肾等功
Infection is an important cause of neonatal diseases and deaths, more common in newborns in the country. To reduce the mortality rate of neonatal infection, the key is the right early antimicrobial drugs. How to get the right medicine should first understand the characteristics of pharmacokinetics in newborns. Neonatal pharmacokinetic characteristics of the various parts of the body’s physiology and metabolism has been constantly changing, not only can not be applied to adult pharmacokinetic data in newborns, nor the same dose and usage of drugs One day after birth in preterm infants and full-term newborns 14 days, because of liver and kidney and other two functions