本文研究了影响红霉素可湿性的因素及改进红霉索可湿性的方法。结果表明,提高晶粒密度和控制干燥温度提高了红霉素的水化程度,使可湿性明显提高,红霉素无水物的可湿性相当低,同时,红霉素的溶解速度与可湿性之间存在一定关系,提高可温性可以加速红霉素的溶解,提高药物的生物利用度。 In this paper, we studied the factors affecting the wettability of erythromycin and the methods to improve the wettability of erythromycin. The results showed that increasing the grain density and controlling the drying temperature increased the degree of hydration of erythromycin, significantly improved the wettability, and the wettability of the erythromycin anhydrous was relatively low. Meanwhile, the dissolution rate and wettability of erythromycin There is a certain relationship between, to improve the temperature can accelerate the dissolution of erythromycin and improve the bioavailability of drugs.