目的比较帕罗西汀与多塞平治疗慢性紧张型头痛的临床疗效。方法对60例慢性紧张性头痛进行帕罗西汀和多塞平治疗的临床对照观察,治疗组帕罗西汀剂量为20~40mg·d-1,对照组多塞平为25~75mg·d-1,疗程均为12周,进行头痛程度评分及疗效评价,并观察不良反应。结果帕罗西汀组头痛比多塞平组明显减轻,总有效率分别为93.3%、73.3%,两组差异有显著性意义(P<0.05),并且帕罗西汀组的不良反应比多塞平组少而轻。结论帕罗西汀治疗慢性紧张型头痛的临床疗效较好,副作用轻,值得推广。 Objective To compare the clinical efficacy of paroxetine and doxepin in the treatment of chronic tension-type headache. Methods The clinical observation of paroxetine and doxepin in 60 patients with chronic tension-induced headache was conducted. The paroxetine dose was 20-40 mg · d-1 in the treatment group and 25-75 mg · d-1 in the control group. The treatment course All were 12 weeks, the headache degree score and efficacy evaluation, and observed adverse reactions. Results The headache of paroxetine group was significantly lower than that of doxepin group, with the total effective rates of 93.3% and 73.3%, respectively. There was significant difference between the two groups (P <0.05), and the side effects of paroxetine were less than that of doxepin group And light. Conclusion Paroxetine is effective in treating chronic tension-type headache with mild side effects and is worth promoting.