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向大鼠蛛网膜下腔注射辣椒素导致一级传入纤维中的Ｃ纤维变性后，用免疫电镜技术在大鼠脊髓后角浅层内观察到：（１）大量含甲啡肽的轴突终末与未标记树突（或棘）形成对称性（少数为非对称性）突触；（２）含甲啡肽的轴突终未与变性终末共同会聚于同一甲啡肽阴性树突；（３）少量含甲啡肽轴突终末与变性终末间形成轴－轴突触或接触；（４）变性终末与含甲啡肽的树突形成非对称性轴－树突触；（５）甲啡肽阴性轴突终末与变性终末会聚于同一未标记树突并与变性终末间形成轴－轴突触或接触．以上结果表明，在脊髓后角内，脑啡肽除主要以突触后抑制方式调节Ｃ纤维传入外，也可通过轴－轴突触或接触对Ｃ纤维传入进行突触前抑制；非甲啡肽能神经元也能对Ｃ纤维传入进行突出后又突触前抑制．此外，Ｃ纤维在脊髓后角内可通过兴奋性轴－树突触直接影响甲啡肽能中间神经元的活性．
Subcutaneous injection of capsaicin into the subarachnoid of rats resulted in C-fibrosis in primary afferent fibers. Immuno-electron microscopy was used to observe the presence of capsaicin-containing axons in the superficial layers of the posterior horn of the rat spinal cord: (1) The terminal and unlabeled dendrites (or spine) form symmetry (a few asymmetric) synapses; (2) the end of the axon containing the metorphin does not coalesce with the terminal denaturation of the same metreotide-negative dendrites ; (3) a small number of terminal methotrexate-containing axon axons and denatured terminals to form axial-axon contact or contact; (4) denatured terminals and dendrites containing the formation of emodin asymmetric axonal-dendritic contact ; (5) The methanolecule-negative axon terminal and the denatured terminal converge on the same unlabeled dendrite and form an axon-axon contact or contact with the denatured terminal. The above results show that in the dorsal horn of the spinal cord, enkephalin can presynaptically inhibit C-fiber afferent via axial-axon contact or contact besides regulating the C fiber afferent mainly in a postsynaptic manner. Meningopeptidine neurons can also highlight C-cell postsynaptic and presynaptic inhibition. In addition, C fibers directly affect the activity of the interneurons of the met-enkephalin via excitatory axis-dendrites in the dorsal horn of the spinal cord.