论文部分内容阅读
1982年,Ghendon和Mikhailovskaya报道硫酸卡那霉素A对鸡胚细胞的家禽空斑病毒有微弱的作用。另有报道指出某些在分子上带有较高级烷基和酰基的化合物具有诸如免疫佐剂活性、干扰素诱导作用以及抗病毒等生物活性。基于这些报道,作者试图把亲脂特性引入氨基糖苷抗生素探讨其抗病毒性能。作者合成了一系列1-N-酰基-3″-N-三氟乙酰卡那霉素A衍生物(1,R=各种长链酰基)并测定了它们对疱疹单性病毒Ⅰ型(HSV-Ⅰ)和流感病毒的抗病毒活性。
In 1982, Ghendon and Mikhailovskaya reported that kanamycin sulfate has a weak effect on avian plague virus in chicken embryo cells. It has also been reported that certain compounds having higher alkyl and acyl groups on the molecule have biological activities such as immune adjuvant activity, interferon induction and antiviral activity. Based on these reports, the authors attempted to introduce lipophilicity into aminoglycoside antibiotics to explore their antiviral properties. The authors synthesized a series of derivatives of 1-N-acyl-3 "-N-trifluoroacetyl kanamycin (1, R = various long chain acyl groups) and tested their effect on herpes simplex virus type 1 -I) and the antiviral activity of influenza virus.