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半个多世纪以来，人们就已经注意到恶性肿瘤很少转移到诸如肝硬化这样受到损伤的肝脏。1942年，Lisa等报告782例恶性肿瘤尸检中仅发现6例肝硬化发生继发性肝肿瘤。他们认为硬化的肝脏并非肿瘤细胞转移的合适场所。Lieber通过5092％恶性肿瘤尸检证实肝脏转移发生率为28．6％，而
For more than half a century, it has been noticed that malignant tumors rarely metastasize to damaged livers such as cirrhosis. In 1942, Lisa et al. reported that only 6 cases of secondary hepatic neoplasms of liver cirrhosis were found in autopsy of 782 cases of malignant tumors. They believe that hardened liver is not a suitable place for tumor cell metastasis. Lieber’s autopsy of 5092% of malignant tumors confirmed that the incidence of liver metastases was 28.6%.