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近年来,肿瘤干细胞(cancer stem cell,CSC)学说研究认为CSC与肿瘤发生、发展、转移和复发关系极为密切。研究还发现CSC具有明显的异质性,即CSC可分为增生、耐药、侵袭和转移等行为不同的亚群细胞,其中具有转移生物学特性的CSC亚群细胞称为肿瘤转移干细胞(migrating cancer stem cell,MCSC)。目前认为,上皮-间质转变、趋化因子和靶器官微环境可能在肿瘤转移过程中起着重要作用。针对MCSC及其相关机制的靶向治疗有望能更有效地遏制肿瘤的转移。
In recent years, studies on the theory of cancer stem cells (CSC) suggest that CSC is closely related to tumorigenesis, development, metastasis and recurrence. The study also found that CSC has obvious heterogeneity that CSC can be divided into proliferative, drug resistance, invasion and metastasis of different subpopulations of cells, which have metastatic biological characteristics of CSC subpopulation cells called metastasis stem cells (migrating cancer stem cell, MCSC). Currently, epithelial-mesenchymal transition, chemokines and target organ microenvironment may play an important role in tumor metastasis. Targeted therapies targeting MCSC and its related mechanisms are expected to more effectively arrest tumor metastases.