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为探讨孕期饮酒对胚胎生长发育的影响,应用植入后全胚胎培养(w hole em bryo culture, WEC)进行研究。将孕9.5天龄鼠胚胎移植于酒精终浓度分别为0、0.40、1.00、2.00、4.00g/L的全胚胎培养基中,于体外培养48小时,观察酒精对胚胎发育和器官形态分化影响。结果表明酒精对胚胎发育具有明显影响且呈剂量-效应关系,0.40g/L组胚胎生长发育指标和器官形态分化指标与对照组差异无显著性(P> 0.05) ,1.00g/L组显著影响中脑、前脑、神经管、卵黄囊循环和翻转等指标,2.00g/L以上组各指标显著低于对照组(P< 0.05) ,胚胎致畸率和死亡率显著增高。结论认为酒精具有发育毒性和致畸性,酒精作用的主要靶器官是脑,酒精对卵黄囊发育分化和DNA合成的影响可能与其发育异常有关
To investigate the influence of drinking during pregnancy on the growth and development of embryos, W hole em bryo culture (WEC) was used to study the effects of drinking during pregnancy. Embryos of 9.5-day-old embryos were transplanted in whole embryo medium with final concentrations of 0, 0.40, 1.00, 2.00 and 4.00 g / L respectively. The embryos were cultured in vitro for 48 hours. The effects of alcohol on embryonic development and morphological differentiation were observed. The results showed that alcohol had a significant effect on embryonic development and showed a dose-effect relationship. There was no significant difference in embryo growth and development and morphological differentiation between the control group and 0.40 g / L group (P> 0.05) Midbrain, forebrain, neural tube, yolk sac circulation and turnover. The indexes of 2.00g / L group were significantly lower than those of the control group (P <0.05), and the embryonic teratogenic rate and mortality were significantly increased. The conclusion is that alcohol has developmental toxicity and teratogenicity, and the main target organ of alcohol action is brain. The effect of alcohol on development and differentiation of yolk sac and DNA synthesis may be related to its developmental abnormality