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目的:探讨Survivin在判断非小细胞肺癌(NSCLC)的病情及预后中的价值。方法:对NSCLC组织50例应用免疫组织化学染色法检测Survivin的表达,并分析其与各项临床因素以及预后的关系。结果:Survivin在NSCLC组织中表达的阳性率为78.0%(39/50);Survivin在NSCLC组织的表达状况与患者的性别、年龄、肿瘤分布、肿瘤直径、组织学分类、分化程度和p-TNM分期无关,P>0.05;生存率的单因素分析显示,Survivin的表达状况(P=0.035)、p-TNM分期(P=0.000)与患者的预后相关;生存率的多因素分析显示,Survivin的表达状况(P=0.027)、p-TNM分期(P=0.000)是影响患者预后的独立指标。结论:NSCLC患者术后生存率受Survivin表达、p-TNM分期等多种因素的影响。Survivin表达是影响患者预后的独立指标。
Objective: To investigate the value of Survivin in judging the condition and prognosis of non-small cell lung cancer (NSCLC). Methods: The expression of Survivin was detected by immunohistochemical staining in 50 cases of NSCLC and its relationship with various clinical factors and prognosis. Results: The positive rate of Survivin expression in NSCLC was 78.0% (39/50). The expression of Survivin in NSCLC was correlated with the gender, age, tumor distribution, tumor diameter, histological classification, differentiation and p-TNM Survivin expression (P = 0.035) and p-TNM stage (P = 0.000) were related to the prognosis of patients. Univariate analysis of survival rate showed that Survivin Expression status (P = 0.027), p-TNM stage (P = 0.000) were independent prognostic indicators. Conclusion: The postoperative survival rate of NSCLC patients is influenced by many factors such as Survivin expression and p-TNM stage. Survivin expression is an independent prognostic indicator.