某些人类免疫缺陷疾病是遗传的,而不象AIDS那样是获得性的。这些遗传疾病中的一部分与X染色体上的位点连锁,并导致灾难性疾患。由于免疫球蛋白基因和T-细胞受体基因本身都不是性连锁,因此有人认为X-连锁的疾病位点可能含有影响淋巴细胞发育的调节基因。最近,Cohen等的二个报告支持这个假设。他们发现,分离出来的X-连锁顺序在淋巴细胞中随发育而表达,并在一个X-连锁免疫缺陷的小鼠模型中有 Some human immunodeficiency diseases are inherited and are not as acquired as AIDS. Some of these genetic diseases are linked to sites on the X chromosome and cause catastrophic disease. Since neither the immunoglobulin gene nor the T-cell receptor gene itself is sexually linked, it has been suggested that X-linked disease sites may contain regulatory genes that affect lymphocyte development. Recently, two reports by Cohen et al. support this hypothesis. They found that the isolated X-linked sequence was expressed in lymphocytes with development and was found in an X-linked immunodeficient mouse model.