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为了探讨体液免疫反应在高原肺水肿（HAPE）的发病机理中是否起作用，我们用单项免疫扩散定量测定法对49例患者血清及其中8例的肺泡灌洗液中免疫球蛋白（IgG、IgA、IgM）与补作（C3、C4、C5、C9）含量进行测定，并用荧光比色法测定其中8例的血浆与肺泡灌洗液中组胺与5—羟色胺（5－HT）含量。结果：HAPE患者血清与肺泡灌洗液中IgG，IgM,C3，C4，以及血浆与肺泡灌洗液中组胺含量均显著增高（P＜0．01），C5、C9增高（P＜0．05），治愈后，血液中上述物质均降至对照组水平（P＞0．05），肺泡灌洗液未复查。提示：体液免疫反应在HAPE的发病机理中有非常重要的作用。鉴于HAPE在体液免疫反应参与下的发病机理与Ⅲ型超敏反应的发病机理相同，我们认为，HAPE可能为超敏反应Ⅲ型疾病的肺部表现，但尚须深入研究确定。
In order to investigate whether humoral immune response plays a role in the pathogenesis of high altitude pulmonary edema (HAPE), we used single immunodiffusion quantitative assay to detect the serum levels of immunoglobulins (IgG, IgA , IgM and complement (C3, C4, C5, C9) were measured. The content of histamine and 5-hydroxytryptamine (5-HT) in plasma and bronchoalveolar lavage fluid of 8 patients were determined by fluorescence colorimetry. Results: The contents of IgG, IgM, C3 and C4 in serum and alveolar lavage fluid of patients with HAPE and histamine in plasma and alveolar lavage fluid increased significantly (P <0.01) and C5 and C9 increased (P <0. 05). After the cure, the above substances in the blood were all reduced to the level of the control group (P> 0.05). The alveolar lavage fluid was not examined. Hint: The humoral immune response plays a very important role in the pathogenesis of HAPE. Given the same pathogenesis of HAPE as humoral immune response and the pathogenesis of type III hypersensitivity, we believe that HAPE may be a lung manifestation of hypersensitivity type III disease, but we still have to study it in depth.