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目的：探讨限制进食后体重快速回升的机理。方法：下丘脑腹内侧核损伤性（ＶＭＨ）肥胖大鼠给予其正常进食量的５０％饲养６天后，收集血样，分析胆固醇、甘油三酯、游离脂肪酸、血浆消瘦素、胰岛素和脂蛋白脂酶的水平和活性。结果：在限制进食后，ＶＭＨ肥胖大鼠体重和血浆消瘦素、胆固醇、甘油三酯以及游离脂肪酸明显下降；肝脏分泌甘油三酯减少，同时血浆中甘油三酯清除加快。但是，血浆胰岛素水平和肝素后脂蛋白脂酶活性并没有下降，仍然维持在很高的水平上。结论：虽然限制进食能够减轻体重、体内脂肪量，降低血浆胆固醇、甘油三酯浓度，但并不能降低血浆胰岛素水平和脂蛋白酯酶活性，即不能消除或减轻脂肪合成亢进的危机。这是停止限制进食、转入正常进食后，体重快速回升的生化基础。
Objective: To explore the mechanism of rapid weight gain after restriction of eating. Methods: Hypothalamic rats with ventricular injury (VMH) were fed 50% normal diet for 6 days. Blood samples were collected for analysis of cholesterol, triglycerides, free fatty acids, plasma leptin, insulin and lipoprotein lipase The level and activity. Results: The body weight, plasma leptin, cholesterol, triglycerides and free fatty acids in obese VMH rats decreased significantly after restricted feeding. The hepatic secretion of triglycerides decreased and plasma triglyceride clearance accelerated. However, plasma insulin levels and heparin-induced lipoprotein lipase activity did not decline, still maintaining a high level. CONCLUSIONS: Although restriction on eating can reduce body weight, body fat mass, and plasma cholesterol, triglyceride concentrations, it does not reduce plasma insulin levels and lipoprotein lipase activity, ie, can not eliminate or reduce the risk of hyperthyroidism. This is to stop limiting eating, into the normal diet, the rapid rebound in weight biochemical basis.