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目的：研究肝素的抗过敏作用，开发其临床新用途。方法：用卵白蛋白（ Ｏｖａｌｂｕ ｍｉｎ ，ＯＡ） 免疫豚鼠使之致敏，以ＯＡ 攻击诱发过敏性哮喘，观察肝素延长哮喘潜伏期的作用；取致敏豚鼠离体回肠，ＯＡ 攻击产生过敏性收缩，观察肝素对该收缩的抑制作用。结果：与Ｎ－Ｓ 组比较，肝素８００ＩＵ／Ｌ 组和４００ＩＵ／Ｌ 组能显著延长呼吸困难的潜伏期和抽搐跌倒的潜伏期（ Ｐ 分别小于０－０１ 和０－０５） ；肝素１６ ０００ＩＵ／Ｌ 组、８ ０００ＩＵ／Ｌ 组能显著降低回肠平滑肌的收缩高度（ Ｐ 分别小于０－０１ 和０－０５） 。结论：肝素具有抗过敏作用。
Objective: To study the anti-allergic effect of heparin and to develop new clinical uses. Methods: Guinea pigs were sensitized with ovalbumin (OA), allergic asthma was induced by OA challenge, and the effect of heparin on prolonging the latent period of asthma was observed. Allergenic contraction was induced by isolated ileum and OA in sensitized guinea pigs The inhibitory effect of heparin on this contraction. Results: Compared with N-S group, the incubation period of 800dU / L and 400IU / L heparin significantly prolonged the latency of dyspnea and convulsions fall (P <0-01 and 0-05 respectively); heparin 16000IU / L group , 8 000 IU / L group can significantly reduce the ileum smooth muscle contraction height (P less than 0-01 and 0-05). Conclusion: Heparin has an anti-allergic effect.