铅是一种Na~+/K~+-ATP酶的可逆性抑制剂,铅工人红细胞膜Na~+/K~+-ATP酶活性的降低已有报道,作者观察到酶活性的增强,这与Hasan,Seccki等体内外研究结果都相反,为了弄清这种酶活性与血液学之间的关系,对31名职业性接铅男工作了研究,并以50名铁路男工做对照,结果铅作业组酶活性,血铅、尿铅、尿δ-ALA以及尿卟啉值均显著高于对照组(P<0.01);铅作业组酶活性与血铅浓度呈正相关(r=0.473,P<0.01);细胞内 Lead is a reversible inhibitor of Na ~ + / K ~ + -ATPase. The reduction of Na ~ + / K ~ + -ATPase activity in the erythrocyte membrane of lead workers has been reported. The authors observed an increase in enzyme activity, which In contrast to the in vitro and in vivo results of Hasan and Seccki et al., In order to clarify the relationship between this enzyme activity and hematology, 31 occupational male lead workers were studied and compared to 50 railway male workers. Results The activity of lead, blood lead, urinary lead and urinary δ-ALA and urinary porphyrin in lead group were significantly higher than those in control group (P <0.01). There was a positive correlation between enzyme activity and blood lead level in lead group (r = 0.473, P <0.01); intracellular