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为了研究辅助化疗后Ⅱ期结肠癌患者的生存情况和预后影响因素,Jee SH等开展了相应研究,共纳入了363例行根治性手术的Ⅱ期结肠癌患者。其中308例加行辅助化疗(辅助化疗组):静脉滴注5-氟尿嘧啶(500 mg/m2)和甲酰四氢叶酸(20 mg/m2),每天2 h,连续5 d,再停用3周,共6个周期;另55例仅行根治性手术(手术组)。高危患者需满足以下条件中的一项或多项:T4期肿瘤、低分化肿瘤、淋巴血管浸润、神经浸润、穿孔、梗阻或淋巴结清扫数量小于12枚。研究结果:所有
To study the survival and prognostic factors of patients with stage II colon cancer after adjuvant chemotherapy, Jee SH et al. Conducted a series of studies enrolling 363 patients with stage II colon cancer undergoing radical surgery. 308 patients received adjuvant chemotherapy (adjuvant chemotherapy): intravenous drip of 5-Fluorouracil (500 mg / m2) and leucovorin (20 mg / m2) for 2 h everyday for 5 consecutive days and then discontinued 3 Week, a total of 6 cycles; the other 55 cases only radical surgery (surgery group). High-risk patients need to meet one or more of the following conditions: T4 tumor, poorly differentiated tumor, lymphatic vascular invasion, nerve infiltration, perforation, obstruction or lymph node dissection number less than 12. Findings: All