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目的 探讨肿瘤坏死因子Thr2 6Asn多态性与中国人缺血性脑卒中之间的关系。方法 利用PCR技术和分子杂交技术对北京地区 2 94例缺血性脑卒中患者进行肿瘤坏死因子 β (TNFβ)Thr2 6Asn多态性的检测和分析 ,并与 2 79例北京地区的非脑卒中对照比较。结果 缺血性脑卒中患者TNFβThr2 6Asn多态性位点 2 6Asn携带者基因型频率明显高于非脑卒中对照。结论 TNFβThr2 6Asn多态性可能是中国人群中缺血性脑卒中发病的遗传学危险因素。
Objective To investigate the relationship between Thr2 6 Asn polymorphism of tumor necrosis factor and Chinese ischemic stroke. Methods The polymorphisms of Thr2 6 Asn in tumor necrosis factor β (TNFβ) of 2 94 ischemic stroke patients in Beijing area were detected and analyzed by PCR and molecular hybridization. The results were compared with those of non-stroke control subjects in Beijing Compare Results The frequencies of genotypes of 26Asn carriers in TNFβThr2 6Asn polymorphism sites in ischemic stroke patients were significantly higher than those in non-stroke patients. Conclusions TNFβThr2 6Asn polymorphism may be a genetic risk factor for ischemic stroke in Chinese population.