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慢性应激或长期外源性应激激素糖皮质类固醇处理可以引起机体神经精神系统功能失调 ,导致衰老过程加速、学习记忆障碍、阿尔茨海默病、抑郁等疾患 ,其中应激激素对海马的选择性损伤是导致这些疾患发生的关键原因 ,表现为海马出现糖皮质激素 (GC)受体下调、神经元萎缩甚至缺失等退化性变化 ,其机制可能与GC及继发性释放的兴奋性氨基酸 (EAA)协同作用 ,最终使神经营养因子 (如NGF)表达低下有关。本文就慢性应激诱发衰老及相关疾患机制的研究进展进行综述。
Chronic stress or long-term exogenous stress hormone glucocorticoid treatment can cause the body nervous system dysfunction, leading to accelerated aging process, learning and memory disorders, Alzheimer’s disease, depression and other diseases, including stress hormone on the hippocampus Selective damage is the key reason leading to these disorders. The degenerative changes of glucocorticoid receptor (GC), hippocampal atrophy and even deletion in hippocampus may occur. The mechanism may be related to GC and the secondary release of excitatory amino acids (EAA) synergism, eventually leading to the low expression of neurotrophic factors (such as NGF). This review summarizes the research progress on the mechanism of chronic stress-induced senescence and related disorders.