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To the editor:The endometrial lesion and uterus prolapsed of young woman presents a distinct feature in uterus prolapsed of systemic lupus erythematosus (SLE) patients,but it is receiving little consideration.To our knowledge,there are few reported cases of women with endometrial lesion and SLE.We here reported a case of endometrial complex hyperplasia and uterus prolapsed pelvic organ prolapse quantification system (POP-Q) stage Ⅲ of a 24-year-old woman with SLE.